A mechanistic kinetic description of lactate dehydrogenase elucidating cancer diagnosis and inhibitor evaluation
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چکیده
منابع مشابه
Kinetic studies of rabbit muscle lactate dehydrogenase.
A number of reports have appeared in recent years on the mechanism, i.e. the mode of enzyme and substrate interaction, of anaerobic dehydrogenases. For example, the mechanisms of heart muscle lactate dehydrogenase (1)) yeast alcohol dehydrogenase (2), and ribitol dehydrogenase (3) appear to involve a compulsory sequence of enzyme and substrate interaction leading to one or more kinetically impo...
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High rates of aerobic glycolysis represent a key mechanism by which endometrial cancer cells consume glucose as its primary energy source. The up-regulated glycolytic pathway is a common therapeutic target whose inhibition has implications for anti-tumor activity in cancer cells. The present study was aimed at evaluating the potential of a novel lactate dehydrogenase (LDH) inhibitor, Galloflavi...
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BACKGROUND AND AIM: This study is conducted aiming to assess and compare the salivary levels of malondialdehyde (MDA) and lactate dehydrogenase (LDH) in active and passive smokers to determine the correlation between environmental tobacco smoke and health condition. METHODS: This study evaluated 75 healthy individuals inc...
متن کاملKinetic and mechanistic studies of methylated liver alcohol dehydrogenase.
Reductive methylation of lysine residues activates liver alcohol dehydrogenase in the oxidation of primary alcohols, but decreases the activity of the enzyme towards secondary alcohols. The modification also desensitizes the dehydrogenase to substrate inhibition at high alcohol concentrations. Steady-state kinetic studies of methylated liver alcohol dehydrogenase over a wide range of alcohol co...
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ژورنال
عنوان ژورنال: Journal of Enzyme Inhibition and Medicinal Chemistry
سال: 2017
ISSN: 1475-6366,1475-6374
DOI: 10.1080/14756366.2016.1275606